|
Cell-cell
adherens |
|
Page
updated 19/2/03 |
| Cell-cell
adherens
junctions are just one adhesion type others include the desmosome and
focal contact. Cell-cell adherens attach the actin filament system
from one cell to that of a neighbouring cell. Like the focal
contact, the adherens junction also performs signalling functions.
 Focal
Contact Wnt
signalling
|
 |
Figure 1. Cell-cell
adherens - The main structural components |
| Protein |
Function |
Reference |
| a-actinin |
An
F-actin bundling protein |
|
| ADIP |
An
afadin and a-actinin
binding protein |
Asada
et al, 2003 |
| Afadin |
|
Mandai
et al, 1997 |
| |
|
|
| Nexilin |
|
|
| Radixin |
|
|
| ZO-2 |
|
Itoh
et al, 1999 |
| Table
1 Cell -cell Adherens Junction Proteins |
|
|
|
|
References:-
Asada, M., Irie, K., Morimoto, K., Yamada, A.,
Ikeda, W., Takeuchi, M. & Takai, Y. (2003) ADIP, a novel afadin- and a-actinin-binding
protein localized at cell-cell adherens junctions., J.Biol.Chem. 278,
4103-4111.
Fannon, A. M., Sherman, D. L., Ilyina-Gragerova,
G., Brophy, P. J., Friedrich jr, V. L. & Colman, D. R. (1995) Novel E-cadherin-mediated
adhesion in peripheral nerve: Schwann cell architecture is stabilized by
autotypic adherens junctions. J.Cell Biol. 129, 189-202.
Guvakova, M. A., Adams, J. C. & Boettiger, D.
(2002) Functional role of {alpha}-actinin, PI 3-kinase and MEK1/2 in
insulin-like growth factor I receptor kinase regulated motility of human
breast carcinoma cells. J Cell Sci. 115, 4149-4165.
Hunter, C., Sung, P., Schejter, E. D. &
Wieschaus, E. (2002) Conserved domains of the Nullo protein required for
cell-surface localization and formation of adherens junctions. Mol.Biol.
Cell. 13, 146-157.
Itoh, M., Morita, K. & Tsukita, S. (1999)
Characterization of ZO-2 as a MAGUK family member associated with tight as
well as adherens junctions with a binding affinity to occludin and a-catenin.
J.Biol.Chem. 274, 5981-1986.
Krendel, M., Gloushankova, N. A., Bonder, E. M.,
Feder, H. H., Vasiliev, J. M. & Gelfand, I. M. (1999) Myosin-dependent
contractile activity of the actin cytoskeleton modulates the spatial
organization of cell-cell contacts in cultured epitheliocytes. PNAS. 96,
9666-9670.
Krendel, M. F. & Bonder, E. M. (1999)
Analysis of actin filament bundle dynamics during contact formation in
live epithelial cells. Cell Motility Cytoskeleton. 43, 296-309.
Mandai, K., Nakanishi, H., Satoh, A., Obaishi,
H., Wada, M., Nishioka, H., Itoh, M., Mizoguchi, A., Aoki, T., Fujimoto,
T., Matsuda, Y., Tsukita, S. & Takai, Y. (1997) Afadin: A novel
actin-filament-binding protein with one PDZ domain localized at cadherin-based
cell-to-cell adherens junction. J. Cell Biol. 139, 517-528.
Ohtsuka, T., Nakanishi, H., Ikeda, W., Satoh, A.,
Momose, Y., Nishioka, H. & Takai, Y. (1998) Nexilin: A novel actin
filament-binding protein localized at cell-matrix adherens junction.
J.Cell Biol. 143, 1227-1238.
Rüdiger, M. (1998) Vinculin and a-actinin:
shared and unique functions in adherens junctions. BioEssays. 20,
733-740.
Sahai, E. & Marshall, C. J. (2002) ROCK and
Dia have opposite effects on adherens junctions downstream of Rho. Nature
Cell Biol. 4, 408-415.
Takahashi, K., Nakanishi, H., Miyahara, M.,
Mandai, K., Satoh, K., Satoh, A., Nishioka, K., Aoki, J., Nomoto, A.,
Mizoguchi, A. & Takai, Y. (1999) Nectin/PRR: An Immunoglobulin-like
Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions
through Interaction with Afadin, a PDZ Domain-containing Protein. J.
Cell Biol. 145, 539-549.
Takai, Y. & Nakanishi, H. (2003) Nectin and
afadin: novel organizers of intercellular junctions. J Cell Sci. 116,
17-27.
Tsukita, S., Hieda, Y. & Tsukita, S. (1989) A
New 82-kD Barbed End-capping Protein (Radixin) Localized in the
Cell-to-Cell Adherens Junction: Purification and Characterization. J.Cell
Biol. 108, 2369-2382.
Waterman-Storer, C. M., Salman, W. C. &
Salman, E. D. (2000) Feedback interactions between cell-cell adherens
junctions and cytoskeletal dynamics in newt lung epithelial cells. Mol.Biol.Cell.
11, 2471-2483. |
|
