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These ADF/cofilin
(ACs) group of actin-binding proteins are particularly complex in their
relationship with actin in its various forms. ACs can both
stimulate polymerisation and depolymerisation depending on the
conditions (particularly pH). Two recent very comprehensive reviews
have been published. One from Jim
Bamburg, one of the original
discoverers of the ADF/Cofilins (Bamburg,
1999), the
other from Tom Pollard's lab (Pollard,
Blanchoin and Mullins, 2000)
. Click here for a
table summarizing the properties of the ADF/cofilin family members
Left. A human
Gial cell stained red cofilin, green nucleus, Celestial Yap
Yeast cofilin N terminus blue to C terminaus red.
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