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The ADF/Cofilin Homepage
These ADF/cofilin (ACs) group of actin-binding proteins are particularly complex in their relationship with actin in its various forms.  ACs can both stimulate polymerisation and depolymerisation depending on the conditions (particularly pH). Two recent very comprehensive reviews have been published. One from Jim Bamburg, one of the original discoverers of the ADF/Cofilins (Bamburg, 1999), the other from Tom Pollard's lab (Pollard, Blanchoin and Mullins, 2000) . Click here for a table summarizing the properties of the ADF/cofilin family members

Left. A human Gial cell stained red cofilin, green nucleus, Celestial Yap
Yeast cofilin N terminus blue to C terminaus red.

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