Serum Response Factor and Actin Expression

Serum Response Factor and Actin Expression.

Serum Response Factor (SRF), is a transcription factor belonging to the MADS box family that regulates the expression of actin, many actin-binding proteins, and other proteins (see Table 1 for ABPs). SRF itself is modulated by signals received from actin filament dynamics (Sotiropoulos et al, 1999).

Protein	Function	References:-
Actin
Dystrophin		Gavagni et al, 1997

Vinculin


Table 1 Actin-Binding Proteins regulated by SRF

References:-

Galvagni, F., Lestingi, M., Cartocci, E. & Oliviero, S. (1997) Serum response factor and protein-mediated DNA bending contribute to transcription of dystrophin muscle-specific promotor. Mol.Cell.Biol. 17, 1731-1743.

Schratt, G., Philippar, U., Berger, J., Schwarz, H., Heidenreich, O. & Nordheim, A. (2002) Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J.Cell Biol. 156, 737-750.

Sotiropoulos, A., Gineitis, D., Copeland, J. & Treisman, R. (1999) Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell. 98, 159-169.