mRNA localization and the Cytoskeleton

It has long been known that some mRNAs are associated and immobilized by the cytoskeleton.  In eggs cells, specific mRNAs are enriched by their association with the cytoskeleton, at particular parts of the cell so that for example cells that subsequently arise from the animal pole contain mRNAs 

Arn, E. A. & Macdonald, P. M. (1998) Motors driving mRNA localization: New insights from in vivo imaging. Cell. 95, 151-154.

Azad, A. K., Tani, T., Shiki, N., Tsuneyoshi, S., Urushiyama, S. & Ohshima, Y. (1997) Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe. Mol.Biol.Cell. 8, 825-841.

Bassel, G. J., Powers, C. M., Taneja, K. L. & Singer, R. H. (1994) Single mRNAs visualized by ultrastructural in situ hybridization are principlally localized at actin filament intersections in fibroblasts.  J.Cell Biol. 126, 863-876.

Bassell, G. & Singer, R. H. (1997) mRNA and cytoskeletal filaments. Curr.Oppin.Cell Biol. 9, 109-115.

Belot, N., Rorive, S., Doyen, I., Lefranc, F., Bruyneel, E., Dedecker, R., Micik, S., Brotchi, J., Decaestecker, C., Salmon, I., Kiss, R. & Camby, I. (2001) Molecular characterization of cell substratum attachments in human glial tumors relates to prognostic features. Glia. 36, 375-390.

Bohl, F., Kruse, C., Frank, A., Ferring, D. & Jansen, R.-P. (2000) She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3. EMBO J. 19, 5514-5524.

Costa, A. & Schedl, P. (2001) Conservation signals location. Nature. 414, 593-595.

Deshler, J. O., Highett, M. I., Abramson, T. & Schnapp, B. J. (1998) A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates. Current Biol. 8, 489-496.

Fages, C., Kaksonen, M., Kinnunen, T., Punnonen, E.-L. & Rauvala, H. (1998) Regulation of mRNA localization by transmembrane signalling: local interaction of HB-GAM (heparin-binding growth-associated molecule) with the cell surface localizes b-actin mRNA.  J.Cell Sci. 111, 3073-3080.

Fulton, A. B. (1993) Spatial organization of the synthesis of cytoskeletal proteins. J.Cell Biochem. 52, 148-152.

Fulton, A. B. & L'Ecuyer, T. L. (1993) Cotranslational assembly of some cytoskeletal proteins: Implications and prospects. J.Cell Sci. 105, 867-871.

Gu, W., Pan, F., Zhang, H., Bassell, G. J. & Singer, R. H. (2002) A predominantly nuclear protein affecting cytoplasmic localization of b-actin mRNA in fibroblasts and neurons. JCB. 156, 41-51.

Han, J. W., Park, J. H., Kim, M. & Lee, J. H. (1997) mRNA for microtubule proteins are specifically colocalized during the sequential formation of basal body, flagella, and cytoskeletal microtubules in the differentiation of Naegleria gruberi.  J.Cell Biol. 137, 871-879.

Havin, L., Git, A., Elisha, Z., Oberman, F., Yaniv, K., Scwartz, S. P., Standart, N. & Yisraeli, J. K. (1998) RNA-binding protein conserved in both microtubule- and microfilament- based RNA localization. Genes & Dev. 12, 1593-1598.

Hill, M. A. & Gunning, P. (1993) Beta and gamma actin mRNAs are differentially located within myoblasts. J.Cell Biol. 122, 825-832.

Hill, M. A., Schedlich, L. & Gunning, P. (1994) Serum-induced signal transduction determines the peripheral localization of b-actin mRNA within the cell. J.Cell Biol. 126, 1221-1230.

Hoock, T. C., Newcomb, P. M. & Herman, I. M. (1991) b-actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury. J.Cell Biol. 112, 653-664.

Kwon, S. & Schnapp, B. J. (2001) RNA localization: SHEdding light on the RNA-motor linkage. Current Biology. 11, R166-R168.

Latham, V. M., Kislauskis, E. H., Singer, R. H. & Ross, A. F. (1994) b-actin mRNA localization is regulated by signal transduction mechanisms. J.Cell Biol. 126, 1211-1219.

Liu, G., Grant, W. M., Persky, D., Latham, J., V.M., Singer, R. H. & Condeelis, J. (2002) Interactions of elongation factor 1a with F-actin and b-actin mRNA: Implications for anchoring mRNA in cell protrusions. Mol.Biol. Cell. 13, 579-592.

Lyubimova, A., Bershadsky, A. D. & Ben-Ze'ev, A. (1999) Autoregulation of actin synthesis requires the 3'-UTR of actin mRNA and protects cells from actin overproduction.  J.Cell.Biochem. 76, 1-12.

Matsumoto, K. & Wolffe, A. P. (1998) Gene regulation by Y-box proteins: coupling control of transcription and translation. Trends Cell Biol. 8, 318-323.

McCarthy, J. E. G. & Kollmus, H. (1995) Cytoplasmic mRNA-protein interactions in eukaryotic gene expression. Trends Biochem. 20, 191-197.

Nagai, K., Oubridge, C., Ito, N., Avis, J. & Evans, P. (1995) The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA. Trends Biochem. 20, 235-240.

Oleynikov, Y. & Singer, R. H. (1998) RNA localization: different zipcodes, same postman? Trends Cell Biol. 8, 381-383.

Rasmussen, C. D. & Means, A. R. (1992) Increased calmodulin levels affect cell morphology and mRNA levels of cytoskeletal protein genes. Cell Mot.Cytoskel. 21, 45-57.

Ross, A. F., Oleynikov, Y., Kislauskis, E. H., Taneja, K. L. & Singer, R. H. (1997) Characterization of a b-actin mRNA zipcode-binding protein. Mol.Biol.Cell. 17, 2158-2165.

Ruzanov, P. V., Evdokimova, V. M., Korneeva, N. L., Hershey, J. W. B. & Ovchinnikov, L. P. (1999) Interaction of the universal mRNA-binding protein, p50, with actin: a possible link between mRNA and microfilaments. J.Cell.Sci. 112, 3487-3496.

Schumacher, J. M., Lee, K., Edelhoff, S. & Braun, R. E. (1995) Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. J.Cell Biol. 129, 1023-1032.

Shestakova, E. A., Singer, R. H. & Condeelis, J. (2001) The physiological significance of b-actin mRNA localization in determining cell polarity and directional motility. PNAS. 98, 7045-7050.

Stewart, O. & Worley, P. F. (2001) A cellular mechanism for targeting newly synthesized mRNAs to synaptic site on dendrites. PNAS. 98, 7062-7068.

Takizawa, P. A., Sil, A., Swedlow, J. R., Herskowitz, I. & Vale, R. D. (1997) Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature. 389, 90-93.

Takizawa, P. A. & Vale, R. D. (2000) The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. PNAS. 97, 5273-5278.

Vedeler, A. & Hollas, H. (2000) Annexin II is associated with mRNAs which may constitute a distinct subpopulation. Biochem.J. 348, 565-572.

Vilela, C., Ramirez, C. V., Linz, B., Rodriques-Pousada, C. & McCarthy, J. E. G. (1999) Post-determination ribosome interactions with the 5'UTR modulate yeast mRNA stability. EMBO J. 18, 3139-3152.

Vilela, C., Velasco, C., Ptushkina, M. & McCarthy, J. E. G. (2000) The eukaryotic mRNA decapping proteinDcp1 interacts physically and functionally with the eIF4F translation initiation complex. MBO J. 19, 4372-4382.

Wilhelm, J. E. & Vale, R. D. (1993) RNA on the move: The mRNA localization pathway. J.Cell Biol. 123, 269-274.

Zhang, H. L., Singer, R. H. & Bassell, G. J. (1999) Neurotrophin regulation of b-actin mRNA and protein localization within growth cones. J.Cell Biol. 147, 59-70.

Zhao, W.-m., Jiang, C., Kroll, T. T. & Huber, P. (2001) A proline-rich protein binds to the localization element of Xenopus Vg1 mRNA and to ligands involved in actin polymerization. EMBO J. 20, 2315-2325.