| A
phosphoinositide-binding domain present in a large number of proteins,
named after phox a PI-binding protein in which the function was first
identified (Xu
et al, 2001).
In addition to binding PI-lipds, some PX domains also contain a PxxP
motif which can be a target for SH3 domain binding, it has been shown
that such a motif within the PX region of p47phox binds its
own C-terminus through a SH3 interaction (Hiroaki
et al, 2001).
|
| Reference:-
Ellson, C. D.,
Andrews, S., Stephens, L. R. & Hawkins, P. T. (2002) The PX domain:
a new phosphinositide-binding module. J.Cell Sci. 115,
1099-1105.
Hiroaki, H.,
Ago, T., Ito, T., Sumimoto, H. and Kohda, D. (2001). Solution structure
of the PX domain, a target of the SH3 domain. Nat.Struct.Biol. 8,
526-530.
Xu, Y., Seet, L.-F., Hanson, B.
& Hong, W. (2001) The Phox homology (PX) domain, a new player in
phosphoinositide signalling. Biochem. J. 360, 513-530. |
