ABP280, Filamin, Gyronemin

A large (270kd) dimeric actin crosslinking protein from a variety of sources.  Filamin crosslinks microfilaments into an orthogonal gel without  producing bundles, presumably because the filaments are linked at right angle to each other.  Like ABP-120, filamin has an actin binding headpiece close to the N-terminus followed by b-cross structures. Whereas in ABP-120 there are six domains, in filamin there are 24 of these structures.

Table 1

References:-

Cunningham, C. C., Gorlin,  J. B., Kwiatkowski, D. J., Hartwig, J. H., Janmey, P. A., Byers, H. R. & Stossel, T. P. (1992). “Actin-binding protein requirement for cortical stability and efficient locomotion.” Science 255, 325-327.

Fox, J.W., Lamperti, E.D., Eksioglu, Y.Z., Hong, S.E., Feng, Y., Graham, D.A., Scheffer, I.E., Dobyns, W.B., Hirsch, B.A., Radtke, R.A., Berkovic, S.F., Huttenlocher, P.R. & Walsh, C.A. (1998). "Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia." Neuron 21, 1315-1325.

Goldmann, W. H. and  Isenberg, G. (1993). “Analysis of filamin and a-actinin binding to actin by the stopped flow method.” FEBS letters 336(3), 408-410.

Gorlin, J., Yamin, J., Egan, S., Stewart, M., Stossel, T., Kwiatkowski, D. & Hartwig, J. (1990). "Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leafspring." J.Cell Biol. 111, 1089-1105.

Gorlin, J. B., E. Henske, E., Warren, S. T., Kunst, C. B., Durso, M., Palmieri, G., Hartwig, J. H., Bruns, G. & Kwiatkowski, D. J. (1993). “Actin-binding protein (abp-280) filamin gene (fln) maps telomeric to the color-vision locus (r/gcp) and centromeric to g6pd in xq28.” Genomics: 496-498.

Guo, Y., Zhang, S.X., Sokol, N., Cooley, L.& Boulianne, G.L.(2000)."Physical and genetic interaction of filamin with presenilin in Drosophila." J.Cell Sci. 113, 3499-3508.

Leedman, P. J., B. Faulkner-Jones, B., Cram, D.S., Harrison, P.J., West, J., O'Brien, E., Simpson, R., Coppel, R.L., & Harrison, L.C. (1993). “Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins.” PNAS.USA 90, 5994-5998.

Lebart, M. C., C. Méjean, C., Casanova, D., Audemard, E., Derancourt, J., Roustan, C.& Benyamin, Y.(1994). “Characterization of the actin binding site on smooth muscle filamin.” J. Biol. Chem. 269, 4279-4284.

Leonardi, A., H. Ellinger-Ziegelbauer, H., Franzoso, G., Brown, K. & Siebenlist, U. (2000). “Physical and functional interaction of filamin (actin-binding protein 280) and tumor necrosis factor receptor-assoicated factor 2.” J.Biol.Chem. 275(1), 271-278 

Li, M.-g., Serr, M., Edards, K., Ludmann, S., Yamamotot, D., Tilney, L.G., Field, C.M. & Hays, T.S. (1999). " Filamin is required for ring canal assembly and actin organization during Drosophila oogenesis." J.Cell Biol. 146(5), 1061-1074.

Liu, Y.-M., Thomas, L., Warren, R.A., Enns, C.A., Cunningham, C.C., Hartwig, J.H. & Tomas, G. (1997). "Cytoskeletal protein ABP-280 directs the intramolecular trafficing of furin and modulates proprotein processing in the endocytic pathway." J.Cell Biol. 139, 1719-1733.

Marti, A., Z. Luo, Z., Cunningham, C., Ohta, Y., Hartwig, J., Stossel, T.P., Kyriakis, J.M. & Avruch, J. (1997). “Actin -binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-a activation of SAPK in melanoma cells.” J.Biol.Chem. 272(5), 2620-2628.

Méjean, C.,  Lebart, M.C., Poyer, M., Roustan, C. & Benyamin, Y. (1992). “Localization and identification of actin structures involved in the filamin-actin interaction.” Eur.J.Biochem. 209, 555-562.

Meyer, S.C., Zuerbig, S., Cunningham, C.C., Hartwig, J.H., Bissell, T., Gardner, K. & Fox, J.E.B.(1997). "Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein Iba." J.Biol.Chem. 272, 2914-2919

Ohta, Y., N. Suzuki, N. Nakamura, S., Hartwig, J.H. & Stossel, T.P. (1999). “The small GTPase Ral1 targets filamin to induce filopodia.” PNAS USA 96, 2122-2128.

 Ohta, Y., T. P. Stossel, T., & Hartwig, J.H. (1991). “Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor i (FcgR1).” Cell 67, 275-282.

Stahlhut, M. and B. van Deurs (2000). “Identification of filamin as a novel ligand for caveolin-1: Evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton.” Mol.Biol.Cell 11, 325-337.