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An
actin binding protein that binds only the b-isoform
of actin (Shuster et
al, 1996).
The cDNA encodes a protein with an expected molecular weight of some 150kDa, but
the protein was originally isolated as a 73kDa protein (hence the name) (Welch
& Herman, 2002).
b-CAP73
has six predicted ankyrin-like repeats at the N-terminus.
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References:-
Riley, K. N., Maldonado, A. E., Tellier, P., D'Souza-Schorey, C. & Herman, I. M.
(2003) bcap73-ARF6 interactions modulate cell shape
and motility after injury in vitro. Mol Biol Cell. 14, 4155-4161.
Shuster,
C.B., Lin, A.Y., Nayak, R., & Herman, I.M. (1996). b-CAP73:
A novel b
actin-specific binding protein. Cell Motil.Cytoskeleton 35,
175-187.
Welch,
A. Y. & Herman, I. M. (2002) Cloning and characterization of bCAP73,
a novel regulator of b-actin
assembly. Int. J. Biochem.Cell Biol. 1233.
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