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A
family of actin binding proteins related to the "bullous pemphigoid
antigen", (BPAG). An unusual protein family in that members
connect the three main cytoskeletal elements (microfilament, microtubules and
intermediate filaments) by binding to all three! (Houseweart
& Cleveland, 1999).
Members of this family include BPAG1n1, BPAG1n2, BPAG1n3, ACF7 and plectin (a
more distant relation). These proteins are large (c300-500kD)
characterised by coiled coil domains.
Figure 1.
ABP actin-binding site, M microtubule-binding site, IF
intermediate filament binding site.
Some BPAG
members connect the intermediate filament belt at desmosomes and hemidesmosomes
(Figure 2)
References:-
Houseweart, M. K. & Cleveland, D. W. (1999)
Cytoskletal linkers: New MAPs for old destinations., Current Biology. 9,
R864-R866.
Fuchs, E. & Yang, Y. (1999) Crossroads on
cytoskeletal highways, Cell. 98, 547-550.
Yang, Y., Dowling, J., Yu, Q.-C., Kouklis, P.,
Cleveland, D. W. & Fuchs, E. (1996) An essential cytoskeletal linker protein
connecting actin microfilaments to intermediate filaments, Cell. 86,
655-665.
Yang, Y., Bauer, C., Strasser, G., Wollman, R., Julien,
J.-P. & Fuchs, E. (1999) Integrators of the cytoskeleton that stabilize
microtubules, Cell. 98, 229-238.
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