CEACAM1
is a homotypic, type 1 trans-membranous cell adhesion molecule with two
differentially spliced isoforms consisting of 3 or 4 Ig-like domains. A
GST fusion protein including the cytoplasmic region of short isoform
(CEACAM1-S) bound F-actin with a Kd of 7mM,
when assayed by actin
co-sedimentation (Schumann
et al, 2001).
The actin binding site has been localised to 419-432:-
FLHFGKTGSSGPLQ
No obvious similarity
between this actin-binding region and others exist. The
cytoplasmic region of CEACAM1 also binds tropomyosin.
References:-
Schumann, D., Chen, C.-J., Kaplan, B.
& Shively, J. E. (2001) Carcinoembryonic antigen cell adhesion
molecule 1 directly associates with cytoskeleton proteins actin and
tropomyosin. J.Biol.Chem. 276, 47421-47433.
