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A
component of the epithelial tight junction (Citi
et al, 1988; 1989)
that binds ZO-1, ZO-2, ZO-3, myosin II (Cordenonsi
et al, 1999),
and actin (D'Arti
& Citi, 2001).
Cingulin is thought to form a parallel dimer with globular head and tail region
separated by a rod-like central region (Cordenonsi
et al, 1999).
Cingulin is thought to cross-link actin into a sedimentable complex with actin
possibly through a region within residues 101-296 in the dimer. No
similarity between known actin-binding domains in other ABPs and this region of
cingulin was detected (D'Arti
& Citi, 2001).
References:-
Citi, S., Sabanay, H., Kendrick-Jones, J. & Geiger,
B. (1989) Cingulin: characterization and localization, J.Cell Sci. 93,
107-122.
Citi, S., Sabanay, H., Jakes, R., Geiger, B. &
Kendrick-Jones, J. (1988) Cingulin, a new peripheral component of tight
junctions, Nature. 333, 272-276.
Cordenonsi, M., D'Arti, F., Hammar, E., Parry,
D. A., Kendrick-Jones, J., Shore, D. & Citi, S. (1999) J.Cell Biol. 147,
1569-1582.
D'Arti, F. & Citi, S. (2001) Cingulin
interacts with F-actin in vitro., FEBS letters. 507, 21-24.
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