Extracted
from the sea hare (mollusc, nudibranch) Dolabella auricularia, (-)-doliculide is an
actin-binding drug that competes with phalloidin for binding (Bai et
al, 2002). The drug like the Dolastatins isolated from the
same sea hare doliculide is suspected of actually accumulating in the
sea hare from cyanobacteria it is feeding on. The structure of
(-)-doliculide is similar to Jasplakinolide and the Chondramides that
also compete with phalloidin for actin binding.
From
Bai et al, 2002
Reference:-
Bai, R., Covell,
D. G., Liu, C., Ghosh, A. K. & Hamel, E. (2002) (-)-Doliculide, a
new macrocyclic depsipeptide enhancer of actin assembly. J. Biol.
Chem. 277, 32165-32171.
From
Bai et al, 2002