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EAST
is an EGF receptor substrate that binds actin (as does the EGF receptor
its self - see below). The name comes from EGFR-Associated
protein with SH3 and TAM domains, and is not to be
confused with another protein called EAST that is a nucleoskeletal
protein (part of the nuclear matrix) (see Lasky,
2000). As
the name implies EAST binds the EGF receptor directly (Lohi
et al, 1998).
The N-terminus of EAST is responsible for binding actin (Lohi
& Lehto, 1998).
EAST also binds Eps15 another ABP (see below). EAST is enriched at focal
adhesions and in some cells (MDCK) at cell-cell contacts (Lohi
& Lehto, 1998).
References:-
Lasky,
L.A. (2000) The nucleoskeleton: go EAST, young man. Nature Cell
Biology, 2, E74-E75.
Lohi,
O., Poussu, A., Merilainen, J., Kellokumpu, S., Wasenius, V.-M. and
Lehto, V.-P. (1998) "" J.Biol.Chem. 273,
14806-14816.
Lohi,
O. & Lehto, V.-P. (1998) "EAST, a novel EGF receptor substrate,
associates with focal adhesions and actin filaments." FEBS
letters. 436, 419-423. |
