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A
heat shock protein that not only binds actin but has structural homology with
the overall actin and hexokinase fold (Holmes
et al, 1993).
Interestingly, hexokinase also binds actin. All these proteins may well be
related to a bacterial protein - the prokaryote ancestor for actin?
References:-
Xiang, W. & Rensing, L. (1999) Changes in cell
morphology and actin organization during heat shock in Dictyostelium
discoideum: does HSP70 play a role in aquired thermotolerance?, FEMS
letters. 178, 95-107.
Eddy,
R. J., Sauterer,
R. A. & Condeelis,
J. S. (1992)
Cloning and Sequencing of an HSP70 Related Protein from Dictyostelium;
Relationship to Aginactin, an Agonist-Regulated Capping Protein,
J Cell Biol.
abstracts in press
Holmes, K. C., Sander,
C. & Valencia, A. (1993) A new ATP-binding fold in actin, hexokinase and
Hsc70, Trends Cell Biol. 3, 53-59.
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