| An
RNA-binding protein that binds actin (Percipalle
et al, 2001),
and the Balbiani Ring (BR) particle, in both the nucleus and the
cytoplasm. Hrp36 is added cotranscriptionally with BR-specific
mRNA and transported into the cytosol via the nuclear pore. As
actin contains two leptomyxin sensitive nuclear export signals (Wada
et al, 1998),
it is possible that the BR particle is directed out of the nucleus via
these sites on actin. |
| References:-
Percipalle, P., Zhao, J., Pope, B.,
Weeds, A., Lindberg, U. & Daneholt, B. (2001) Actin bound to the
heterogeneous nuclear ribonucleoprotein hrp36 is associated with
Balbiani ring mRNA from the gene to polysomes. J.Cell Biol. 153,
229-236.
Wada, A., Fukuda, M., Mishima, M.
& Nishida, E. (1998) Nuclear export of actin; a novel mechanism
regulating the subcellular localization of a major cytoskeletal protein.
EMBO J. 17, 1635-1641. |
