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During
embryogenesis in Drosophila (and other dipterans), "cellularization"
occurs where each previously synchronously dividing nuclei within the syncitial
embryo, becomes enveloped in its own membrane. This process has been
compared to cytokinesis (Sisson et al, 1999).
The process is driven by actin:myosin II interaction but other specialised ABPs
have been implicated by association, amongst them gelsolin (Stella
et al, 1994), anillin (Field
et al, 1995), and nullo (Postner
& Wieschaus, 1994). Nullo was first
identified through... Although not yet shown to interact with actin directly, it
seems likely.
Reference:-
Field,
C.M.& Alberts, B.M.(1995). "Anillin, a contractile ring protein that
cycles from the nucleus to the cell cortex." J.Cell Biol. 131,
165-178.
Hunter,
C., Sung, P., Schejter, E. D. & Wieschaus, E. (2002) Conserved domains of
the Nullo protein required for cell-surface localization and formation of
adherens junctions., Mol.Biol. Cell. 13, 146-157.
Postner,
M.A. & Wieschaus, E.F. (1994). "The nullo protein is a component of the
actin-myosin network that mediates cellularization in Drosophila melanogaster
embryos." J.Cell Sci. 107, 1863-1873.
Rose,
L.S. & Wieschaus, E. (1992). "The Drosophila cellularization
gene nullo produces a blastoderm-specific transcript whose levels respomd to the
nucleoplasmic ratio." Genes Dev. 6, 1255-1268.
Simpson,
L. & Wieschaus, E. (1990). "Zygotic activity of the nullo locus
is required to stabilize the actin-myosin network during cellularization in Drosophila
embryos." Development 110, 851-863.
Sisson,
J.C., Rothwell, W.F. & Sullivan, W. (1999). "Cytokinesis: Lessons from
Rappaport and the Drosophila blastoderm embryo." Cell Biol Int.
23(12), 871-876.
Stella,
M. C., H. Schauerte, et al. (1994). “Identification of secreted and cytosolic
gelsolin in Drosophila.”
J. Cell Biol. 125,
607-616.
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