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An
actin-binding protein from Salmonella enterica (Mitra
et al, 2000).
SipA shows no obvious homology to any eukaryotic actin-binding protein but binds
actin and also increases the bundling action of fimbrin
(plastin)
by an uncertain mechanism (Zhou
et al, 1999a).
The protein binds actin directly through a C-terminal 226 amino-acid fragment
that increases actin polymerization and decreases depolymerization (Zhou
et al, 1999b).
References:-
McGhie,
E. J., Hayward, R. D. & Koronakis, V. (2001) Cooperation between
actin-binding proteins of invasive Salmonella: SipA potentiates SipC
nucleation and bundling of actin., EMBO J. 20, 2131-2139.
Mitra,
K., Zhou, D., & Galan, J.E. (2000). “Biophysical
characterization of SipA, an actin-binding protein from Salmonella
enterica.” FEBS letters
482: 81-84.
Zhou,
D., Mooseker, M. S. & Galán, J. E. (1999a) An invasion-associated Salmonella
protein modulates the actin-bundling activity of plastin., PNAS. 96,
10176-10181.
Zhou,
D., Mooseker, M. S. & Galan, J. E. (1999b) Role of the Salmonella
actin-binding protein SipA in bacterial internalization., Science. 283,
2092-2095.
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