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First
identified by monoclonals made against gizzard (van
der Loop et al, 1996).
Smoothelin is a minor component of smooth muscle (Wehrens
et al, 1997).
Two
forms of smoothelin exist, smoothelin-A and smoothelin-B expressed in smooth
muscle. The smoothelin gene (Smtn) in mice is on chromosome 11 band A2-A3 by fluorescence
in situ
hybridization (Rensen
et al, 2000). The
actin binding region of the smoothelins are of the CH type found in spectrin a-actinins
and dystrophins.
References
Rensen,
S., Merkx, G., Doevendans, P., Geurts van Kessel, A. & van Eys G. (2000).
"Structure and chromosome location of Smtn, the mouse smoothelin gene."
Cytogenet
Cell Genet 89, 225-229.,
van
der Loop, F.T.L., Schaart, G., Timmer, E.D.J., Ramaekers, F.C.S., & Van Eys,
G.J.J.M. (1996). J.Cell Biol. 134, 401-411.
Wehrens,
X. H. T., Mies, B., Gimona, M., Ramaekers, F. C. S., Van Eys, G. J. J. M. &
Small, J. V. (1997) Localization of smoothelin in avian smooth muscle and
identification of a vascular-specific isoform, FEBS letters. 405,
315-320.
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