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A
100 kDa heat-stable protein enriched in brain and kidney. It has a very high
(~20%) proline content and two PPXY putative WW domain binding motifs. The
association of synaptospondin with actin is not known to be direct but the
protein requires 0.5M NaCl to become free of the actin rich cell pellet and
co-localises with F-actin by immunocytochemistry in a cytochalasin-sensitive
manner (Mundel et
al, 1997).
Another, related protein (Leinweber
et al, 1999)
expressed in smooth muscle, fesselin is a known actin-binding protein (Beall
et al, 2001).
References:-
Beall, B. & Chalovich, J. M. (2001)
Fesselin, a synaptopodin-like protein, stimulates actin nucleation and
polymerization., Biochemistry. 40, 14252-14259.
Leinweber, B. D., Fredrickson, R. S., Hoffman,
D. R. & Chalovich, J. M. (1999) J.Muscle Res. Cell Motil. 20,
539-545.
Mundel, P., Heid, H. W., Mundel, T. M.,
Kruger, M., Reiser, J. & Kriz, W. (1997) Synaptopodin: An actin-associated
protein in telencephalic dendrites and renal podocytes., JCB. 139,
193-204.
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