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Unusually
for an actin filament capping protein, tropomodulin is a pointed end capping
protein found predominantly in muscle cells. Tropomodulin binds actin,
tropomyosin and nebulin (McElhinny
et al, 2001).
References:-
Almenar-Queralt, A., A. Lee, et al. (1999). "Identifiaction
of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament
pointed ends in fast skeletal muscle." J.Biol.Chem. 274(40),
28466-28475.
Kostyukova,
A., Maeda, K., Yamauchi, E., Kreiger, I. & Maeda, Y. (2000) Domain structure
of tropomodulin. Distinct properties of the N-terminal and C-terminal halves., Eur.J.Biochem.
267, 6470-6475.
Krieger,
I., Kostyukova, A., Yamashita, A., Nitanai, Y. & Maeda, Y. (2002) Crystal
structure of the C-terminal half of tropomodulin and structural basis of actin
filament pointed-end capping. Biophys.J. 83, 2716-2725.
McElhinny, A.S., Kolmerer, B., Fowler, V.M., Labeit,
S. & Gregorio, C.C. (2001)." The N-terminal end of nebulin interacts
with tropomodulin at the pointed ends of the thin filaments."
J.Biol.Chem.276(1), 583-592.
Weber, A., C. R. Pennise, et al. (1994). "Tropomodulin
caps the pointed ends of actin filaments." J. Cell Biol. 127,
1627-1635.
Weber, A., C. R. Pennise, et al. (1999). "Tropomodulin
increases the critical concentration of barbed end-capped actin filaments by
converting ADP.Pi-actin to ADP-actin at all pointed filament ends." J.Biol.Chem.
274(49), 34637-34645.
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