A
complex of three troponins, troponin C, troponin I and troponin T regulate the
interactions between the thin (actin) and thick filament (myosin) systems during
muscle contraction by moving tropomyosin from between the two. This is
under the tight regulation of calcium working through troponin C (a calmodulin
related protein), both the other troponins (I and T) in the complex bind
actin.
References:-
Al-Hillawi, E., D. G.
Bhandari, et al. (1995). “The effects of phosphorlyation of caridiac troponin-I
on its interactions with actin and cardiac troponin-C.” Eur.J.Biochem.
228, 962-970.
Oliveira,
D.M., Nakaie, C.R., Sousa, A.D., Farah, C.S. and Reinach, F.C. (2000).
"Mapping the domain of troponin T responsible for the activation of
actomyosin ATPase activity. Identification of residues involved in binding to
actin." J.Biol.Chem. 275(36), 27513-27519.
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