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Tubulins
are abundant proteins in eukaryotes, especially in vertebrate brain. Two
main sub types exist a
and b,
these form stable dimer complexes that polymerise to form
microtubules. Microtubules are frequently seen to associate and
co-align with actin filaments and bundles in cells. Several proteins that
bind both microtubules and actin microfilaments (e.g. EF-1a,
MAPs). Recently a subtype of b-tubulin,
bIV-tubulin
has been discovered to be an actin-binding protein .
References:-
Walss-Bass,
C., Prasad, V., Kreisberg, J. I. & Luduena, R. F. (2001) Interaction of the bIV-tubulin
isotype with actin stress fibers in cultured rat kidney mesangial
cells., Cell Motility Cytoskeleton. 49, 200-207.
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