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The
gene encoding this protein was discovered to be mutated in hereditary disease
Wiskott-Aldrich that has given the gene and its protein the name.
References:-
Abdul-Manan,
N., Aghazadeh, B., Liu, G.A., Majumdar, A., Ouerfelli, O., Siminovitch, K.A.
& Rosen, M.K.(1999). "Structure of Cdc42 in complex with the GTPase-binding
domain of the 'Wiskott-Aldrich syndrome' protein." Nature 399,
379-383.
Bi,
E. & Zigmond, S.H. (1999). "Actin polymerization: where the WASP
stings." Curr.Biol. 9, R160-R163.
Castellano,
F., Montcourrier, P., Guillemot, J.C., Gouin, E., Machesky, L., Cossart, P.
& Chavrier, P. (1999). "Inducible recruitment of Cdc42 or WASP to a
cell-surface receptor triggers actin polymerization and filopodium
formation." Curr.Biol. 9, 351-360.
Kato,
M., Mik, H., Imai, K., Nonoyama, S., Suzuki, T., Sasakawa, C. & Takenawa, T.
(1999). "Wiskott-Aldrich syndrome protein induces actin clustering without
direct binding to Cdc42." J.Biol.Chem. 274, 27225-27230.
Linder,
S., Nelson, D., Weiss, M. & Aepfelbacher, M. (1999). "Wiskott-Alsrich
syndrome protein regulates podosomes in primary human macrophages. PNAS USA
96, 9648-9653.
Li,
R., Debreceni, B., Jia, B., Gao, Y., Tigyi, G. & Zheng, Y. (1999).
"Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of
Cdc42." J.Biol.Chem. 274(42), 29648-29654.
Moreau,
V., Frischknecht, F., Reckman, I., Vincentelli, R., Rabut, G., Stewart, D. &
Way, M. (2000). " A complex of N-WASP and WIP integrates signalling
cascades that lead to actin polymerization." Nature Cell Biol. 2,
441-448.
Mott,
H.R., Owen, D., Nietlispach, D., Lowe, P.N., Manser, E., Lim, L. & Laue, E.D.
(1999). "Structure of the small G protein Cdc42 bound to the GTPase-binding
domain of ACK." Nature 399, 384-388.
O'Sullivan,
E., Kinnon, C. & Brickell, P. (1999). "Wiskott-Aldrich syndrome
protein, WASP." Int.J.Biochem.Cell Biol. 31, 383-387.
Ramesh,
N., Anton, I.M., Hartwig, J.H. & Geha, R.S. (1997). "WIP, a protein
associated with Wiskott-Aldrich syndrome protein, induce actin polymerization
and redistribution in lymphoid cells." PNAS USA 94,
14671-14676.
Ramesh,
N., Anton, I.M., Martinez-Quiles, N. & Geha, R.S. (1999). "Waltzing
with WASP." Trends Cell Biol. 9, 15-19.
Rozelle,
A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H., Roth, M.G.,
Luby-Phelps, K., Marriot, G., Hall, A. & Yin, H.L. (2000). "Phosphatidyinositol
4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through
WASP-Arp2/3." Curr.Biol. 10, 311-320.
Tian,
L., Nelson, D.L. & Stewart, D.M. (2000). " Cdc42-interacting protein 4
mediates binding of the Wiskott-Aldrich syndrome protein to microtubules.
J.Biol.Chem. 275(11), 7854-7861.
Yarar,
D., To, W., Abo, A. & Welch, M.D. (1999). "The Wiskott-Aldrich syndrome
protein directs actin-based motility by stimulating actin nucleation with the
Arp2/3 complex." Curr. Biol. 9, 555-558.
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