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A
serine/threonine kinase from Yersinia that binds and is activated by
actin when secreted into eukaryote cells by type III secretion mechanism (Juris
et al, 2000).
Both G and F-actin and G-actin bound to DNase1 are able to activate the kinase.
The C-terminus of the kinase is responsible for actin binding and bacteria
lacking this part of the gene are not virulent (Galyov
et al, 1993).
A region in the C-terminus has reputed homolgy to the ABP coronin.
Actin is one of the substrates for the kinase, and cells transfected with the
kniase have a disrupted actin cytoskeleton and round up. YpkA is not alone
in phosphorylating actin (see actin
kinases).
References:-
Galyov,
E.E., Hakannsson, S., Forsberg, A. & Wolf-Watz, H (1993). ""
Nature 361, 730-732.
Juris,
S.J., Rudolph, A.E., Huddler, D., Orth, K., & Dixon, J.E. (2000). "A
distinctive role for the Yersinia protein kinase: Actin binding, kinase
activation, and cytoskeleton disruption." PNAS 97(17);
9431-9436.
Related
topics within this site:-
Actin kinases |
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Bacterial invasion of cells and the actin cytoskeleton. |
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