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An Ig containing
actin-binding protein that also binds ezrin (Mykkanen
et al, 2001). Palladin is localized in cells to
stress fibers and cell adhesion (Parast & Otey,
2000). Palladin is homologous to myotilin, a
structural protein of the striated muscle Z-disc, but palladin is present in
smooth muscle and non-muscle tissues, where is co-localises to stress
fibres and cell adhesion plaques (Parast &
Otley, 2000).
References:-
Mykkanen, O.-M., Gronholm, M., Ronty, M.,
Lalowski, M., Salmikangas, P., Suila, H. & Carpen, O. (2001)
Characterization of human palladin, a microfilament-associated protein., Mol.Biol.Cell.
12, 3060-3073.
Parast, M. M. & Otey, C. A. (2000)
Characterization of palladin, a novel protein localized to stress fibers and
cell adhesions., J. Cell Biol. 150, 643-655.
Bang, M. L., Mudry, R. E., McElhinny, A. S., Trombitas,
K., Geach, A. J., Yamasaki, R., Sorimachi, H., Granzier, H., Gregorio, C. C.
& Labeit, S. (2001) Myopalladin, a novel 145-kilodalton sarcomeric protein
with mutliple roles in Z-disc and I-band assemblies., J.Cell Biol. 153,
413-427.
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