A
pH and Ca2+ regulated member of the gelsolin super family of actin
filament severing proteins that seems to function specifically to cleave actin
filament to permit vesicles to dock during regulated secretion.
Click
here for a
diagram of the domain structure of the Gelsolin/Villin family.
References:-
Castillo, A. R. D., S. Lemaire, et al. (1990). "Chromaffin
cell scinderin, a novel calcium." EMBO Journal 9(1), 43-52.
Castillo, A. R. D., M. L. Vitale, et al. (1992).
"Ca2+ and pH Determine the Interaction of Chromaffin Cell
Scinderin with Phosphatidylserine and Phosphatidylinositol 4,5,-Biphosphate and
Its Cellular Distribution During Nicotinic-receptor Stimulation and Protein
Kinase C Activation." J.Cell Biol. 119(4), 797-810.
Marcu, M. G., L. Zhang, et al. (1996).
"Recombinant scinderin, an F-actin severing protein, increases
calcium-induced release of serotonin from permeabilized platelets, an effect
blocked by 2 scinderin-derived actin-binding peptides and phosphatidylinositol
4,5-bisphosphate." Blood 87, 20-24.
Rodríguez Del Castillo, A., S. Lemaire, et al. (1990).
"Chromaffin cell scinderin, a novel calcium-dependent actin filament
severing protein." EMBO Journal 9(1), 43-52.
Rodríguez Del Castillo, R., M. L. Vitale, et al.
(1992). "Ca 2+
and pH determine the interaction of chromaffin cell scinderin with
phosphatidylsering and phosphatidylinositol 4,5,-bisphosphate and its cellular
distribution during nicotinic-receptor stimulation and protein kinase C
activation." J. Cell Biol. 119, 797-810.
Sakurai, T., H. Kurokawa, et al. (1991). "The Ca 2+
-dependent Actin Filament-severing Activity of 74-kDa Protein (Adseverin)
Residues in Its NH2
-terminal
Half." J.Biol.Chem. 266(7), 4581-4585.
Tchakarov, L., M.-L. Vitale, et al. (1990).
"Expression of scinderin, an actin filament-severing protein, in different
tissues." FEBS letters 268(1), 209-212.
Trifaró, J. M. (1993). "Scinderin and chromaffin
cell actin network dynamics during exocytosis." J.Neurochem. 61,
187.
Trifaró, J. M., M. L. Vitale, et al. (1993). "Scinderin
and chromaffin cell actin network dynamics during neurotransmitter
release." J.Physiology-paris 87, 89-106.
Vitale, M. L., A. R. D. Castillo, et al. (1991).
"Cortical Filamentous Actin Disassembly and Scinderin Redistribution during
Chromaffin Cell Stimulation Precede Exocytosis, A Phenomenon Not Exhibited by
Gelsolin." J.Cell Biol. 113(5), 1058-1067.
Zhang, L., M. G. Marcu, et al. (1996).
"Recombinant scinderin enhances exocytosis, an effect blocked by 2
scinderin-derived actin-binding peptides and PIP2." Neuron
17, 287-296.
|