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An
actin bundling protein localised to the Z-disc of skeletal muscle (Weins
et al, 2001).
Myopodin is homologous to synaptopodin another actin-associated protein strongly
expressed in the kidney (Mundel
et al, 1997).
The actin-binding region in myopodin has been localised to a central region
between 410-563. This region contain no recognised actin-binding motif and
so may contain yet another actin-binding domain (see Actin-Binding
Motifs) (Weins et
al, 2001).
Myopodin like a few other actin-binding proteins (e.g. ADF/Cofilin) accumulates
in the nucleus upon stress. However, unlike the situation with cofilin,
the nuclear actin "loops" seen in cells with increased myopodin did
stain with phalloidin.
References:-
Mundel, P., Heid, H.
W., Mundel, T. M., Kruger, M., Reiser, J. & Kriz, W. (1997) Synaptopodin: An
actin-associated protein in telencephalic dendrites and renal podocytes., JCB.
139, 193-204.
Weins, A., Schwarz, K., Faul, C., Barisoni,
L., Linke, W. A. & Mundel, P. (2001) Differentiation- and stress-dependent
nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.,
J.Cell Biol. 155, 393-403.
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